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ABAT Antibody

CAT: 0223-19-570Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-19-570Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
NCBI Gene ID
18
Swiss Prot
P80404
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 29-300 of human ABAT (NP_001120920.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
SW480
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 49kDa
Fragment
IgG
Symbol
ABAT
Positive Control 2
A375
Positive Control 3
Mouse liver
Positive Control 4
Mouse kidney
Positive Control 5
Mouse brain
NCBI Official Name
4-aminobutyrate aminotransferase
NCBI Organism
Homo sapiens
Other Product Names
ABAT, GABA-AT, GABAT, NPD009
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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