PARD6A Antibody

• Background:

  This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

• NCBI Gene ID:

  50855

• Swiss Prot:

  Q9NPB6

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  A synthetic peptide of human PARD6A

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  SW620

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 47kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  PARD6A

• Positive Control 2:

  HT-29

• Positive Control 3:

  Jurkat

• Positive Control 4:

  U-251MG

• Positive Control 5:

  Raji

• Positive Control 6:

  Mouse testis

• NCBI Official Name:

  Par-6 family cell polarity regulator alpha

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PARD6A, PAR-6, TAX40, PAR-6A, TIP-40, PAR6alpha, par-6 partitioning defective 6 homolog alpha (C.elegans), Tax interaction protein 40, par-6 (partitioning defective 6, C.elegans) homolog alpha, PAR6A

• Tested Applications:

  WB

• Physical Properties:

  Liquid