ABCC5 Antibody

CAT: 0223-18-910Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-18-910Size:100 µL
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Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9- (2-phosphonylmethoxyethyl) adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
10057
Swiss Prot
O15440
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human ABCC5 (NP_005679.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
Mouse brain
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 185kDa
Fragment
IgG
Applications Notes
WB: 1:1000 - 1:2000
Symbol
ABCC5
Positive Control 2
Mouse lung
Positive Control 3
Rat brain
NCBI Official Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
NCBI Organism
Homo sapiens
Other Product Names
ABCC5, ATP-binding cassette, sub-family C (CFTR/MRP), member 5, ABC33, DKFZp686C1782, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11, sub-family C, canalicular multispecific organic anion transporter C
Tested Applications
WB
Physical Properties
Liquid

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