CDK1 Antibody

• Background:

  The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  983

• Swiss Prot:

  P06493

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 208-258 of human CDK1 (NP_001777.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cell Cycle, Immunology, Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HL-60

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 34kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000IHC: 1:50 - 1:200

• Symbol:

  CDK1

• Positive Control 2:

  HeLa

• Positive Control 3:

  THP-1

• Positive Control 4:

  Rat spleen

• NCBI Official Name:

  Cyclin-dependent kinase 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CDC2, CDC28A, CDK1, DKFZp686L20222, MGC111195, CDC2, P34CDC2

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid