MYO7A Antibody

• Background :

  This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID :

  4647

• Swiss Prot :

  Q13402

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 850-1150 of human MYO7A (NP_000251.3) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  Mouse testis

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 254kDa

• Fragment :

  IgG

• Applications Notes :

  WB: 1:500 - 1:2000

• Symbol :

  MYO7A

• Positive Control 2 :

  Rat testis

• NCBI Official Name :

  Myosin VIIA

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  DFNA11, DFNB2, MYOVIIA, MYU7A, NSRD2, USH1B, unconventional myosin-VIIa, myosin VIIA (Usher syndrome 1B (autosomal recessive, severe) )

• Tested Applications :

  WB

• Physical Properties :

  Liquid