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NR0B2 Antibody

CAT: 0223-18-340Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-18-340Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
NCBI Gene ID
8431
Swiss Prot
Q15466
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human NR0B2 (NP_068804.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Transcription
Purification
Affinity purification
Positive Control
Mouse liver
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 28kDa
Fragment
IgG
Symbol
NR0B2
Positive Control 2
Rat liver
Positive Control 3
Rat testis
NCBI Official Name
Nuclear receptor subfamily 0, group B, member 2
NCBI Organism
Homo sapiens
Other Product Names
NR0B2, SHP, SHP1
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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