EIF6 Antibody

• Background:

  Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.

• NCBI Gene ID:

  3692

• Swiss Prot:

  P56537

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human EIF6 (NP_852133.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience

• Purification:

  Affinity purification

• Positive Control:

  U-251MG

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 27kDa

• Fragment:

  IgG

• Symbol:

  EIF6

• Positive Control 2:

  HeLa

• Positive Control 3:

  293T

• Positive Control 4:

  HepG2

• Positive Control 5:

  K-562

• NCBI Official Name:

  Eukaryotic translation initiation factor 6

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CAB, EIF3A, ITGB4BP, b (2) gcn, eIF-6, p27 (BBP), p27BBP, eukaryotic translation initiation factor 6, B4 integrin interactor, eukaryotic translation initiation factor 3A, p27 beta-4 integrin-binding protein

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid