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NFKB2 Antibody, KO Validated

CAT: 0223-18-252Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-18-252Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB) . The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
4791
Swiss Prot
Q00653
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 690-899 of human NFKB2 (NP_002493.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction, Transcription, Inflammasomes
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 125kDa
Fragment
IgG
Symbol
NFKB2
NCBI Official Name
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NCBI Organism
Homo sapiens
Other Product Names
NFKB2, p52, p105, H2TF1, LYT10, CVID10, LYT-10, NF-kB2
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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