RUNX1T1 Antibody

• Background:

  This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  862

• Swiss Prot:

  Q06455

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 100-390 of human RUNX1T1 (NP_783554.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Transcription

• Purification:

  Affinity purification

• Positive Control:

  HepG2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 67kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:200 - 1:1000

• Symbol:

  RUNX1T1

• Positive Control 2:

  SH-SY5Y

• NCBI Official Name:

  Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  RUNX1T1, CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1

• Tested Applications:

  WB

• Physical Properties:

  Liquid