RUNX1T1 antibody

RUNX1T1 antibody

• Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). Can repress transactivation mediated by TCF12(PubMed:16803958). Acts as a negative regulator of adipogenesis(By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal(PubMed:23812588).
• Synonyms: Protein CBFA2T1|Cyclin-D-related protein|Eight twenty one protein|Protein ETO|Protein MTG8|Zinc finger MYND domain-containing protein 2|RUNX1T1|AML1T1|CBFA2T1|CDR|ETO|MTG8|ZMYND2
• CAS Number: 9007-83-4
• Gene ID: 862
• UniProt: Q06455
• Host: Rabbit
• Reactivity: Human, Mouse
• Immunogen: runt-related transcription factor 1; translocated to, 1(cyclin D-related)
• Target: RUNX1T1
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, WB, IHC
• Field of Research: Metabolism
• Purification: Immunogen affinity purified
• Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 70-75 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)