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COL4A3 Antibody

CAT: 0223-16-569Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-16-569Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
NCBI Gene ID
1285
Swiss Prot
Q01955
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1600 to the C-terminus of human COL4A3 (NP_000082.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 162kDa
Fragment
IgG
Symbol
COL4A3
NCBI Official Name
Collagen, type IV, alpha 3
NCBI Organism
Homo sapiens
Other Product Names
COL4A3, collagen, type IV, alpha 3 (Goodpasture antigen), collagen IV, alpha-3 polypeptide, collagen alpha-3 (IV) chain, tumstatin
Tested Applications
WB, IF
Physical Properties
Liquid

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