TAP2 Antibody

CAT: 0223-16-428Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-16-428Size:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
NCBI Gene ID
6891
Swiss Prot
Q03519
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 430-680 of human TAP2 (NP_000535.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
CEM
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 76kDa
Fragment
IgG
Symbol
TAP2
Positive Control 2
MCF7
Positive Control 3
Mouse spleen
Positive Control 4
Mouse lung
NCBI Official Name
Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
NCBI Organism
Homo sapiens
Other Product Names
TAP2, ABC transporter, MHC 2, ABCB3, APT2, Antigen peptide transporter 2, D6S217E, ABC18, Ham2, Peptide supply factor 2, Peptide transporter PSF2, Peptide transporter TAP2, PSF2, Y1, PSF-2, RING11
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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