UPF3A Antibody

• Background:

  This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD) . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  65110

• Swiss Prot:

  Q9H1J1

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 327-476 of human UPF3A (NP_075387.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  Mouse testis

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 55kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  UPF3A

• NCBI Official Name:

  UPF3 regulator of nonsense transcripts homolog A (yeast)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  UPF3A, UPF3 regulator of nonsense transcripts homolog A, OTTHUMP00000018789, UPF3, RENT3A, HUPF3A, UPF3 regulator of nonsense transcripts homolog A (yeast), UPF3A

• Tested Applications:

  WB

• Physical Properties:

  Liquid