RTN3 Antibody

• Background :

  This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.

• NCBI Gene ID :

  10313

• Swiss Prot :

  O95197

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RTN3 (NP_006045.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Apoptosis, Cell Cycle, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  HeLa

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 26kDa

• Fragment :

  IgG

• Applications Notes :

  WB: 1:500 - 1:2000

• Symbol :

  RTN3

• NCBI Official Name :

  Reticulon 3

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  RTN3, ASYIP, ASY interacting protein, HAP, NSP-like protein II, NSPL2, RTN3-A1, NSP-like protein 2, Reticulon-3, Homolog of ASY protein, NSPLII, Reticulon 3

• Tested Applications :

  WB

• Physical Properties :

  Liquid