PRKAG3 Antibody

• Background:

  The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.

• NCBI Gene ID:

  53632

• Swiss Prot:

  Q9UGI9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PRKAG3 (NP_059127.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Autophagy, Cancer, Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Fragment:

  IgG

• Applications Notes:

  IF: 1:50 - 1:100

• Symbol:

  PRKAG3

• NCBI Official Name:

  Protein kinase, AMP-activated, gamma 3 non-catalytic subunit

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PRKAG3, protein kinase, AMP-activated, gamma 3 non-catalytic subunit, AMPKG3, 5'-AMP-activated protein kinase, gamma-3 subunit, AMP-activated protein kinase, non-catalytic gamma-3 subunit, AMPK gamma-3 chain

• Tested Applications:

  IF

• Physical Properties:

  Liquid