COMP Antibody

• Background :

  The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) .

• NCBI Gene ID :

  1311

• Swiss Prot :

  P49747

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human COMP (NP_000086.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Signal Transduction, Stem Cell

• Purification :

  Affinity purification

• Positive Control :

  SKOV3

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 105kDa

• Fragment :

  IgG

• Symbol :

  COMP

• Positive Control 2 :

  LO2

• Positive Control 3 :

  U-87MG

• Positive Control 4 :

  HL-60

• Positive Control 5 :

  Mouse skeletal muscle

• Positive Control 6 :

  Rat testis

• NCBI Official Name :

  Cartilage oligomeric matrix protein

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  EDM1, EPD1, MED, PSACH, THBS5, TSP5, cartilage oligomeric matrix protein, cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple), pseudoachondroplasia (epiphyseal dysplasia 1, multiple), thrombospondin-5

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid