COMT Antibody

CAT: 0223-14-710Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-14-710Size:100 µL
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Background
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT) . The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
NCBI Gene ID
1312
Swiss Prot
P21964
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 42-221 of human COMT (NP_009294.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
MCF-7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 25kDa, 30kDa
Fragment
IgG
Symbol
COMT
Positive Control 2
HT-29
Positive Control 3
THP-1
Positive Control 4
A-431
Positive Control 5
HepG2
Positive Control 6
Mouse liver
NCBI Official Name
Catechol-O-methyltransferase
NCBI Organism
Homo sapiens
Other Product Names
COMT, catechol-O-methyltransferase, HEL-S-98n
Tested Applications
WB, IP
Physical Properties
Liquid

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