COMT Antibody

• Background:

  Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT) . The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

• NCBI Gene ID:

  1312

• Swiss Prot:

  P21964

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 42-221 of human COMT (NP_009294.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  MCF-7

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 25kDa, 30kDa

• Fragment:

  IgG

• Symbol:

  COMT

• Positive Control 2:

  HT-29

• Positive Control 3:

  THP-1

• Positive Control 4:

  A-431

• Positive Control 5:

  HepG2

• Positive Control 6:

  Mouse liver

• NCBI Official Name:

  Catechol-O-methyltransferase

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  COMT, catechol-O-methyltransferase, HEL-S-98n

• Tested Applications:

  WB, IP

• Physical Properties:

  Liquid