ATP1A2 Antibody

• Background:

  The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.

• NCBI Gene ID:

  477

• Swiss Prot:

  P50993

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human ATP1A2 (NP_000693.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  U-87MG

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 112kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  ATP1A2

• Positive Control 2:

  OVCAR3

• Positive Control 3:

  Mouse heart

• Positive Control 4:

  Mouse lung

• Positive Control 5:

  Mouse testis

• Positive Control 6:

  Rat heart

• NCBI Official Name:

  ATPase Na+/K+ transporting subunit alpha 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  FHM2, MHP2, sodium/potassium-transporting ATPase subunit alpha-2, ATPase Na+/K+ transporting alpha 2 polypeptide, Na (+) /K (+) ATPase alpha-2 subunit, Na+/K+ ATPase, alpha-A (+) catalytic polypeptide, Na+/K+ ATPase, alpha-B polypeptide, sodium pump subunit alpha-2, sodium-potassium ATPase catalytic subunit alpha-2, sodium/potassium-transporting ATPase alpha-2 chain

• Tested Applications:

  WB

• Physical Properties:

  Liquid