ATP2A2 Antibody

• Background:

  This gene encodes one of the SERCA Ca (2+) -ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

• NCBI Gene ID:

  488

• Swiss Prot:

  P16615

• Accession Number:

  P16615

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ATP2A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-403 amino acids from the Central region of human ATP2A2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  115 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ATP2A2

• NCBI Official Name:

  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Tuusa, J.T., et al. FEBS J. 277 (13) :2815-2829 (2010)

• Background Reference 03:

  Godic, A., et al. EurDermatol 20 (3) :271-275 (2010)

• Background Reference 04:

  Godic, A., et al. J. Am. Acad. Dermatol. 62 (5) :819-823 (2010)

• Other Product Names:

  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SERCA2, SR Ca (2+) -ATPase 2, Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca (2+) ATPase, ATP2A2, ATP2B

• Tested Applications:

  WB

• Protein ID:

  114312

• Physical Properties:

  Liquid