SPTA1 Antibody

• Background:

  Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.

• NCBI Gene ID:

  6708

• Swiss Prot:

  P02549

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 940-1160 of human SPTA1 (NP_003117.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  239T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 300kDa

• Fragment:

  IgG

• Symbol:

  SPTA1

• Positive Control 2:

  LO2

• Positive Control 3:

  A-549

• Positive Control 4:

  Mouse kidney

• Positive Control 5:

  Mouse liver

• Positive Control 6:

  Mouse lung

• NCBI Official Name:

  Spectrin alpha, erythrocytic 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  EL2, HPP, HS3, SPH3, SPTA, spectrin alpha chain, erythrocytic 1, alpha-I spectrin, elliptocytosis 2, erythroid alpha-spectrin, spectrin alpha chain, erythrocyte

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid