SPRTN Antibody

• Background:

  The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS) . Alternatively spliced transcript variants have been identified.

• NCBI Gene ID:

  83932

• Swiss Prot:

  Q9H040

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SPRTN (NP_001010984.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  U-87MG

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 60kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  SPRTN

• NCBI Official Name:

  SprT-like N-terminal domain

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  C1orf124, DVC1, PRO4323, spartan, sprT-like domain-containing protein Spartan, DNA damage protein targeting VCP, DNA damage-targeting VCP (p97) adaptor, zinc finger RAD18 domain-containing protein

• Tested Applications:

  WB

• Physical Properties:

  Liquid