CTCF Antibody

• Background :

  This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT) -containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC) -containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID :

  10664

• Swiss Prot :

  P49711

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat, Monkey

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CTCF (NP_006556.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  293T

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 140kDa

• Fragment :

  IgG

• Symbol :

  CTCF

• Positive Control 2 :

  Jurkat

• NCBI Official Name :

  CCCTC-binding factor (zinc finger protein)

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  CTCF, MRD21

• Tested Applications :

  WB, IHC, IF, IP, ChIP

• Physical Properties :

  Liquid