SMAD7 Antibody

• Background:

  The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3) . Several transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  4092

• Swiss Prot:

  O15105

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 220-390 of human SMAD7 (NP_005895.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  SW480

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 46kDa

• Fragment:

  IgG

• Symbol:

  SMAD7

• NCBI Official Name:

  SMAD family member 7

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SMAD7, CRCS3, MADH7, MADH8

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid