SMAD3 Antibody

• Background:

  The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

• NCBI Gene ID:

  4088

• Swiss Prot:

  P84022

• Accession Number:

  P84022

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SMAD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the Central region of human SMAD3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Pig, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SMAD3

• NCBI Official Name:

  Mothers against decapentaplegic homolog 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ge, Q., et al. J. Cell. Physiol. 225 (3) :846-854 (2010)

• Background Reference 02:

  Lee, J., et al. J. Biol. Chem. 285 (34) :26618-26627 (2010)

• Background Reference 03:

  Roder, C., et al. Childs Nerv Syst (2010) In press :

• Background Reference 04:

  Valdes, A.M., et al. Arthritis Rheum. 62 (8) :2347-2352 (2010)

• Other Product Names:

  Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3, SMAD3, MADH3

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  51338669

• Physical Properties:

  Liquid