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SMAD4 Antibody

CAT: 0223-27-474Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-27-474Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SMAD4 is one of the Smad family members, which are essential intracellular signalling components of the transforming growth factor-beta (TGF-beta) superfamily. Smad2 and Smad3 are structurally highly similar and mediate TGF-beta signals. Smad4 is distantly related to Smads 2 and 3, and forms a heteromeric complex with Smad2 after TGF-beta or activin stimulation. TGF-beta induces heteromeric complexes of Smads 2, 3 and 4, and their concomitant translocation to the nucleus, which is required for efficient TGF-beta signal transduction
NCBI Gene ID
4089
Swiss Prot
Q13485
Accession Number
NP_005350
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SMAD4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer, Signal Transduction
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SMAD4 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
60 kDa
Applications Notes
SMAD4 antibody can be used for detection of SMAD4 by ELISA at 1:312500. SMAD4 antibody can be used for detection of SMAD4 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SMAD4
NCBI Official Name
SMAD family member 4
NCBI Organism
Homo sapiens
Background Reference 01
Kantola, A.K., et al., Gene 363, 142-150 (2005) .
Other Product Names
SMAD4, JIP, DPC4, MADH4, MYHRS
Tested Applications
ELISA, WB
Protein ID
4885457
Physical Properties
Liquid

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