GLRB Antibody

• Background:

  This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  2743

• Swiss Prot:

  P48167

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 23-265 of human GLRB (NP_000815.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  U-251MG

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 58kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:1000 - 1:2000

• Symbol:

  GLRB

• Positive Control 2:

  NCI-H460

• Positive Control 3:

  HT-1080

• Positive Control 4:

  THP-1

• Positive Control 5:

  Mouse brain

• Positive Control 6:

  Mouse liver

• NCBI Official Name:

  Glycine receptor subunit beta

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Glycine receptor subunit beta, Glycine receptor 58 kDa subunit, GLRB

• Tested Applications:

  WB

• Physical Properties:

  Liquid