MCFD2 Antibody

• Background:

  This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC) . Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D) ; a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

• NCBI Gene ID:

  90411

• Swiss Prot:

  Q8NI22

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 27-146 of human MCFD2 (NP_644808.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  A375

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 16kDa

• Fragment:

  IgG

• Symbol:

  MCFD2

• Positive Control 2:

  SW480

• Positive Control 3:

  Mouse liver

• Positive Control 4:

  Mouse kidney

• Positive Control 5:

  Rat kidney

• NCBI Official Name:

  Multiple coagulation factor deficiency 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  F5F8D, F5F8D2, LMAN1IP, SDNSF, multiple coagulation factor deficiency protein 2, neural stem cell-derived neuronal survival protein

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid