CRLF2 Antibody

• Background:

  This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP) . Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.

• NCBI Gene ID:

  64109

• Swiss Prot:

  Q9HC73

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 23-231 of human CRLF2 (NP_071431.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Chemokines & Cytokines, Immunology, Innate Immunity

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 50kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:200 - 1:1000

• Symbol:

  CRLF2

• Positive Control 2:

  Jurkat

• Positive Control 3:

  Mouse liver

• Positive Control 4:

  Rat brain

• NCBI Official Name:

  Cytokine receptor like factor 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CRL2Y, TSLPR, CRLF2, cytokine receptor-like factor 2, IL-XR, TSLP receptor, cytokine receptor CRL2 precusor, thymic stromal lymphopoietin protein receptor, thymic stromal-derived lymphopoietin receptor

• Tested Applications:

  WB

• Physical Properties:

  Liquid