HOOK3 Antibody

• Background:

  The HOOK proteins (HOOK1, HOOK2 and HOOK3) comprise a family of cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules mediating the spatial organization of diverse membrane-trafficking systems; their more divergent C-terminal domains mediate binding to organelles (1,2) . HOOK3 exists as a homodimer and participates in defining the architecture and localization of the Golgi complex through its central coiled-coil domain (3) . HOOK3 may regulate clearance of endocytosed receptors such as MSR1 (3,4) .

• NCBI Gene ID:

  84376

• Swiss Prot:

  Q86VS8

• Accession Number:

  NP_115786

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  HOOK3 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1463 - Rat Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  HOOK3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  HOOK3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  HOOK3 antibody is human, mouse and rat reactive. HOOK3 antibody is predicted to not cross-react with HOOK1 and HOOK2.

• Symbol:

  HOOK3

• NCBI Official Name:

  Hook microtubule-tethering protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Walenta JH, Didier AJ, Liu X, et al. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. J. Cell Biol. 2001; 152:923-34.

• Background Reference 02:

  Sano H, Ishino M, Krämer H, et al. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. J. Biol. Chem. 2007; 282:7973-81.

• Background Reference 03:

  Herrmann L, Wiegmann C, Arsalan-Werner A, et al. Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. PLoS One 2015; 10:e0119423.

• Background Reference 04:

  Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, et al. HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. Endocr. Relat. Cancer 2007; 14:445-52.

• Other Product Names:

  Hook microtubule-tethering protein 3, HK3, h-hook3, hHK3, FLJ31058, Protein Hook homolog 3

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  14165274

• Physical Properties:

  Liquid