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JAGN1 Antibody

CAT: 0223-8367-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8367-01Size:0.02 mg
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Background
JAGN1 is the human ortholog of a gene originally identified in Drosophila melanogaster. It is a transmembrane protein that functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Individuals with mutations in the JAGN1 gene causes aberrant myeloid cell homeostasis and severe congenital neutropenia (SCN) (1) . JAGN1-mutant granulocytes are characterized by ultrastructural defects, aberrant N-glycosylation of multiple proteins, and increased apoptosis (1) . Mice lacking this gene could not mount and efficient neutrophil-dependent immune response to a human fungal pathogen (2) .
NCBI Gene ID
84522
Swiss Prot
Q8N5M9
Accession Number
NP_115881
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell, Immunology
Purification
JAGN1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1411 - Mouse Colon Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (95%)
Buffer
JAGN1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
JAGN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
JAGN1 antibody is human, mouse and rat reactive. At least four isoforms of JAGN1 are known to exist; this antibody will detect all but isoform 2.
Symbol
JAGN1
NCBI Official Name
Jagunal homolog 1
NCBI Organism
Homo sapiens
Background Reference 01
Boztug K, Jarvinen PM, Salzer E, et al. JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Nat. Genet. 2014; 46:1021-7.
Background Reference 02
Wirnsberger G, Zwolanek F, Stadlmann J, et al. Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Nat. Genet. 2014; 46:1028-33.
Other Product Names
Jagunal homolog 1
Tested Applications
ELISA, WB, IHC-P
Protein ID
190014601
Physical Properties
Liquid

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