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JAG1 Antibody

CAT: 0223-8059-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8059-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate decisions (1) . Ligands for Notch include JAG1, JAG2 and Delta. JAG1 is one of the DSL (Delta, Serrate, Lag2) transmembrane proteins that can activate Notch. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis (1,2) . JAG1 is widely expressed in adult and fetal tissues and the mutation of the JAG1 gene is associated with Familial Tetrology of Fallot (3) . JAG1 expression is associated with prostate cancer metastasis and is up-regulated in cervical squamous cell carcinoma (4,5) .
NCBI Gene ID
182
Swiss Prot
P78504
Accession Number
NP_000205
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Stem Cell
Purification
JAG1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Buffer
JAG1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
JAG1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
JAG1 antibody is human, mouse and rat reactive. At least two isoforms of JAG1 are known to exist; this antibody will detect both isoforms.
Symbol
JAG1
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Jagged 1
NCBI Organism
Homo sapiens
Background Reference 01
Lai EC. Notch signaling: control of cell communication and cell fate. Development 2004; 131:965-73.
Background Reference 02
Milner LA, Kopan R, Martin DI, et al. A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors. Blood1994; 83:2057-62.
Background Reference 03
Guida V, Chiappe F, Ferese R, et al. Novel and recurrent JAG1 mutations in patients with tetralogy of Fallot. Clin. Genet. 2011; 80:591-4.
Background Reference 04
Santagata S, Demichelis F, Riva A, et al. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res. 2004; 64:6854-7.
Other Product Names
Jagged 1, AGS, AHD, AWS, CD339, HJ1, JAGL1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4557679
Physical Properties
Liquid

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