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PALMD Antibody

CAT: 0223-8237-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8237-01Size:0.02 mg
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Background
Palmdelphin (PALMD) is a member of the paralemmin families that are lipid-anchored proteins having a role in the cell shape control and cell dynamics (1,2) . While Paralemmin proteins typically anchor to the cytoplasm through via palmytoylation and prenylation, PALMD is found predominantly in the cytosol (3) . PALMD is targeted to the nucleus to induce apoptosis in response to DNA damage (3-5) . Abnormal genetic alterations in PALMD are observed in many malignant tumors (5) .
NCBI Gene ID
54873
Swiss Prot
Q9NP74
Accession Number
NP_060204
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
PALMD antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1310 - Human Bladder Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (93%), Pig: (93%), Mouse: (86%)
Buffer
PALMD antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PALMD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
PALMD antibody is human specific. At least two isoforms are known to exist.
Symbol
PALMD
NCBI Official Name
Palmdelphin
NCBI Organism
Homo sapiens
Background Reference 01
Hultqvist G, Ocampo Daza D, Larhammar D, et al. Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One 2012; 7:e41850.
Background Reference 02
Andreu N, Escarceller M, Feather S, et al. PALML, a novel paralemmin-related gene mapping on human chromosome 1p21. Gene 2001; 278:33-40.
Background Reference 03
Hu B, Copeland NG, Gilbert DJ, et al. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. Biochem. Biophys. Res. Commun. 2001; 285:1369-76.
Background Reference 04
Dashzeveg N, Taira N, Lu ZG, et al. Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell Death Dis. 2014; 5:e1221.
Other Product Names
Palmdelphin, C1orf11, FLJ20271, PALML, Paralemnin-like protein
Tested Applications
ELISA, WB, IHC-P
Protein ID
8923243
Physical Properties
Liquid

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