PRRX1 Antibody

• Background:

  The paired related homeobox protein 1 (PRRX1) is a paired-type DNA-binding homeodomain that plays an important role as a key switch for neural cell lineage determination and is essential for development (1,2) . PRRX1 is expressed in a number of undifferentiated mesenchymal cells in mouse embryos and adults (3) . Mice with a disrupted PRRX1 gene show perinatal death with craniofacial and limb malformations (4) . Low PRRX1 expression levels were significantly associated with metastasis and poor prognosis of breast and colorectal cancer (5) .

• NCBI Gene ID:

  5396

• Swiss Prot:

  P54821

• Accession Number:

  NP_073207

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Stem Cell

• Purification:

  PRRX1 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken: (100%)

• Buffer:

  PRRX1 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PRRX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  PRRX1 antibody is human, mouse and rat reactive. At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms.

• Symbol:

  PRRX1

• NCBI Official Name:

  Paired related homeobox 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nohno T, Koyama E, Myokai F, et al. Chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb. Dev. Biol. 1993; 158:254–64.

• Background Reference 02:

  Shimozaki K, Clemenson GD Jr, and Gage FH. Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J. Neurosci. 2013; 33:4066-75.

• Background Reference 03:

  Cserjesi P, Lilly B, Bryson L, et al. MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer. Development 1992; 115:1087–101.

• Background Reference 04:

  Lu MF, Cheng HT, Kern MJ, et al. prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme. Development 1999; 126:495–504.

• Other Product Names:

  Paired related homeobox 1, homeobox protein PHOX1, Paired mesoderm homeobox protein 1, PHOX1, PMX1, PRX1, PRX-1

• Tested Applications:

  ELISA, WB

• Protein ID:

  12707577

• Physical Properties:

  Liquid