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PRRX1 Antibody

CAT: 0223-8093-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8093-01Size:0.02 mg
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Background
The paired related homeobox protein 1 (PRRX1) is a paired-type DNA-binding homeodomain that plays an important role as a key switch for neural cell lineage determination and is essential for development (1,2) . PRRX1 is expressed in a number of undifferentiated mesenchymal cells in mouse embryos and adults (3) . Mice with a disrupted PRRX1 gene show perinatal death with craniofacial and limb malformations (4) . Low PRRX1 expression levels were significantly associated with metastasis and poor prognosis of breast and colorectal cancer (5) .
NCBI Gene ID
5396
Swiss Prot
P54821
Accession Number
NP_073207
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Stem Cell
Purification
PRRX1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (100%)
Buffer
PRRX1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PRRX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
PRRX1 antibody is human, mouse and rat reactive. At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms.
Symbol
PRRX1
NCBI Official Name
Paired related homeobox 1
NCBI Organism
Homo sapiens
Background Reference 01
Nohno T, Koyama E, Myokai F, et al. Chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb. Dev. Biol. 1993; 158:254–64.
Background Reference 02
Shimozaki K, Clemenson GD Jr, and Gage FH. Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J. Neurosci. 2013; 33:4066-75.
Background Reference 03
Cserjesi P, Lilly B, Bryson L, et al. MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer. Development 1992; 115:1087–101.
Background Reference 04
Lu MF, Cheng HT, Kern MJ, et al. prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme. Development 1999; 126:495–504.
Other Product Names
Paired related homeobox 1, homeobox protein PHOX1, Paired mesoderm homeobox protein 1, PHOX1, PMX1, PRX1, PRX-1
Tested Applications
ELISA, WB
Protein ID
12707577
Physical Properties
Liquid

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