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EDA1 Antibody

CAT: 0223-8045-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8045-01Size:0.02 mg
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Background
Ectodysplasin A (EDA1) is a member of the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation (1) . It is a trimeric type II membrane protein that co-localizes with cytoskeletal structures at the lateral and apical surfaces of cells and can be expressed as eight alternatively spliced isoforms in hair follicles and in the epidermis of adult skin (2,3) . EDAs are required during development, and loss or mutation of EDA1 results in a group of developmental disorders identified as ectodermal dysplasia type 1 (4,5) .
NCBI Gene ID
1896
Swiss Prot
Q92838
Accession Number
NP_001390
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
EDA1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1405 - Mouse Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (89%)
Buffer
EDA1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
EDA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
EDA1 antibody is human, mouse and rat reactive. Multiple isoforms of EDA1 are known to exist.
Symbol
EDA
NCBI Official Name
Ectodysplasin A
NCBI Organism
Homo sapiens
Background Reference 01
Kere J, Srivastava AK, Montonen O. X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat. Genet. 1996; 13:409-16.
Background Reference 02
Vincent MC, Biancalana V, Ginisty D, et al. Mutational spectrum of the ED1 gene in X-linked hypohidrotic ectodermal dysplasia. Eur. J. Hum. Genet. 2001; 9:355-63.
Background Reference 03
Ohashi M, Moriya C, Tanahashi K, et al. A new EDA gene mutation in a family of X-linked hypohidrotic ectodermal dysplasia. J. Dermatol. Sci. 2014; 74:175-7.
Background Reference 04
Bayés M, Hartung AJ, Ezer S, et al. The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats. Hum. Mol. Genet. 1998; 7:1661-9.
Other Product Names
Ectodysplasin A, Ectodermal dysplasia protein, ED1, ED1-A1, ED1-A2, EDA1, EDA2, EDA protein, HED, ODT1, STHAGX1, XHED, XLHED
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4503449
Physical Properties
Liquid

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