P2RX7 Antibody

• Background :

  The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1) . This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2) . Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2) . Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4) .

• NCBI Gene ID :

  5027

• Swiss Prot :

  Q99572

• Accession Number :

  NP_002553

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction, Immunology

• Purification :

  P2RX7 antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1212 - 3T3 Cell Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat: (81%)

• Buffer :

  P2RX7 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  P2RX7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment :

  IgG

• Specificity :

  P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.

• Symbol :

  P2RX7

• Positive Control 2 :

  Cat. No. 17-201 - 3T3/BALB Cell Slide

• NCBI Official Name :

  Purinergic receptor P2X, ligand-gated ion channel, 7

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Surprenant A, Rassendren F, Kawashima E, et al. The cytosolic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7) . Science 1996; 272:735-8.

• Background Reference 02 :

  North RA. Molecular physiology of P2X receptors. Physiol. Rev. 2002; 82:1013-67.

• Background Reference 03 :

  Labasi JM, Petrushova N, Donovan C, et al. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol. 168:6436-45.

• Background Reference 04 :

  Basso AM, Bratcher NA, Harris RR, et al. Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety; relevance for neuropsychiatric disorders. Behav. Brain Res. 2009; 198:83-90.

• Other Product Names :

  P2X purinoceptor 7, P2X7, purinergic receptor P2X ligand-gated ion channel 7

• Tested Applications :

  ELISA, WB, ICC, IF

• Protein ID :

  300068987

• Physical Properties :

  Liquid