P2RX7 Antibody

• Background:

  The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1) . This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2) . Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2) . Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4) .

• NCBI Gene ID:

  5027

• Swiss Prot:

  Q99572

• Accession Number:

  NP_002553

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Immunology

• Purification:

  P2RX7 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1212 - 3T3 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat: (81%)

• Buffer:

  P2RX7 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  P2RX7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.

• Symbol:

  P2RX7

• Positive Control 2:

  Cat. No. 17-201 - 3T3/BALB Cell Slide

• NCBI Official Name:

  Purinergic receptor P2X, ligand-gated ion channel, 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Surprenant A, Rassendren F, Kawashima E, et al. The cytosolic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7) . Science 1996; 272:735-8.

• Background Reference 02:

  North RA. Molecular physiology of P2X receptors. Physiol. Rev. 2002; 82:1013-67.

• Background Reference 03:

  Labasi JM, Petrushova N, Donovan C, et al. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol. 168:6436-45.

• Background Reference 04:

  Basso AM, Bratcher NA, Harris RR, et al. Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety; relevance for neuropsychiatric disorders. Behav. Brain Res. 2009; 198:83-90.

• Other Product Names:

  P2X purinoceptor 7, P2X7, purinergic receptor P2X ligand-gated ion channel 7

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  300068987

• Physical Properties:

  Liquid