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P2RX7 Antibody

CAT: 0223-8015-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8015-01Size:0.02 mg
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Background
The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1) . This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2) . Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2) . Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4) .
NCBI Gene ID
5027
Swiss Prot
Q99572
Accession Number
NP_002553
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Immunology
Purification
P2RX7 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1212 - 3T3 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (81%)
Buffer
P2RX7 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
P2RX7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.
Symbol
P2RX7
Positive Control 2
Cat. No. 17-201 - 3T3/BALB Cell Slide
NCBI Official Name
Purinergic receptor P2X, ligand-gated ion channel, 7
NCBI Organism
Homo sapiens
Background Reference 01
Surprenant A, Rassendren F, Kawashima E, et al. The cytosolic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7) . Science 1996; 272:735-8.
Background Reference 02
North RA. Molecular physiology of P2X receptors. Physiol. Rev. 2002; 82:1013-67.
Background Reference 03
Labasi JM, Petrushova N, Donovan C, et al. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol. 168:6436-45.
Background Reference 04
Basso AM, Bratcher NA, Harris RR, et al. Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety; relevance for neuropsychiatric disorders. Behav. Brain Res. 2009; 198:83-90.
Other Product Names
P2X purinoceptor 7, P2X7, purinergic receptor P2X ligand-gated ion channel 7
Tested Applications
ELISA, WB, ICC, IF
Protein ID
300068987
Physical Properties
Liquid

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