Products for Research Use Only
RegisterLogin

Rubicon Antibody

CAT: 0223-7943-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-7943-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation (1) . Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex (2) . Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines (2) .
NCBI Gene ID
9711
Swiss Prot
Q92622
Accession Number
XP_005269431
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
Rubicon antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
Rubicon antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Rubicon antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
Rubicon antibody is human, mouse and rat reactive. Multiple isoforms of Rubicon are known to exist.
Symbol
KIAA0226
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
KIAA0226
NCBI Organism
Homo sapiens
Background Reference 01
Matsunaga K, Saitoh T, Tabata K, et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 2009; 11:385-96.
Background Reference 02
Yang CS, Lee JS, Rodgers M, et al. Autophagy protein Rubicon mediates phagocytic NAPDH oxidase activation in response to microbial infection of TLR stimulation. Cell Host and Microbe 2012; 11:264-76.
Other Product Names
Run domain Beclin-1 interacting and cysteine-rich containing protein, KIAA0226
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
530375960
Physical Properties
Liquid

Related Products

CatalogName
7943PRubicon Peptide
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody
30-580ACPT Antibody
19-580FABP3 Antibody
15-580POMGNT2 Antibody

Alternative Products

CatalogName
abx446738Rubicon (Rubicon) Antibody (Streptavidin)
abx446730Rubicon (Rubicon) Antibody (ALP)
abx446726Rubicon (Rubicon) Antibody (ATTO 633)
abx446729Rubicon (Rubicon) Antibody (ATTO 700)
abx446724Rubicon (Rubicon) Antibody (ATTO 565)
abx446728Rubicon (Rubicon) Antibody (ATTO 680)
MBS809904-01Rubicon Antibody
abx446727Rubicon (Rubicon) Antibody (ATTO 655)
abx446735Rubicon (Rubicon) Antibody (PE/ATTO 594)
MBS8307058-01Anti-Rubicon Antibody

Popular Products