SNCA Antibody

• Background:

  Alpha-Synuclein (SNCA) is a hallmark of Alzheimer's disease (1,2) . It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2) . SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3) . Defects in SNCA are associated with familial Parkinson's disease (4,5) .

• NCBI Gene ID:

  6622

• Swiss Prot:

  P37840

• Accession Number:

  NP_000336

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Apoptosis

• Purification:

  SNCA antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1412 - Mouse Cerebellum Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%)

• Buffer:

  SNCA antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SNCA antibody can be stored at 4˚ C for up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.

• Symbol:

  SNCA

• NCBI Official Name:

  Synuclein, alpha (non A4 component of amyloid precursor)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993; 90:11282-6.

• Background Reference 02:

  Pronin AN, Morris AJ, Surguchov A, et al. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 2000; 275:26515-22.

• Background Reference 03:

  Oaks AW, Frankfurt M, Finkelstein DI, et al. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS One 2013; 8:e60378.

• Background Reference 04:

  Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997; 276:2045-7.

• Other Product Names:

  SNCA Antibody: PD1, NACP, PARK1, PARK4, Alpha-synuclein, Non-A beta component of AD amyloid

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  6806898

• Physical Properties:

  Liquid