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SNCA Antibody

CAT: 0223-7911-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7911-01Size:0.02 mg
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Background
Alpha-Synuclein (SNCA) is a hallmark of Alzheimer's disease (1,2) . It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2) . SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3) . Defects in SNCA are associated with familial Parkinson's disease (4,5) .
NCBI Gene ID
6622
Swiss Prot
P37840
Accession Number
NP_000336
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Apoptosis
Purification
SNCA antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1412 - Mouse Cerebellum Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%)
Buffer
SNCA antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SNCA antibody can be stored at 4˚ C for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.
Symbol
SNCA
NCBI Official Name
Synuclein, alpha (non A4 component of amyloid precursor)
NCBI Organism
Homo sapiens
Background Reference 01
Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993; 90:11282-6.
Background Reference 02
Pronin AN, Morris AJ, Surguchov A, et al. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 2000; 275:26515-22.
Background Reference 03
Oaks AW, Frankfurt M, Finkelstein DI, et al. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS One 2013; 8:e60378.
Background Reference 04
Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997; 276:2045-7.
Other Product Names
SNCA Antibody: PD1, NACP, PARK1, PARK4, Alpha-synuclein, Non-A beta component of AD amyloid
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
6806898
Physical Properties
Liquid

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