SNCG Antibody [1H10D2]

• Background:

  SNCG (also designated gamma-synuclein or breast cancer-specific protein 1), with 127-amino acid protein (about 14 kDa), belongs to the synuclein family, which also includes alpha- and beta- synuclein.Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals, while SNCG is also expressed in many other non-neuronal tissues. SNCG is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.

• NCBI Gene ID:

  6623

• Swiss Prot:

  O76070

• Accession Number:

  O76070

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Ni-NTA purified truncated recombinant SNCG expressed in E. Coli strain BL21 (DE3) .

• Clonality:

  Monoclonal

• Clone:

  1H10D2

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibody is purified by protein A affinity chromatography.

• Concentration:

  Batch dependent

• Buffer:

  Ascitic fluid containing 0.03% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SNCG (breast cancer-specific protein 1) monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1

• Symbol:

  SNCG

• NCBI Official Name:

  Synuclein, gamma (breast cancer-specific protein 1)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Haiyan Liu, Wei Liu, Yinwei Wu. Cancer Res. 2005 Sep 1;65 (17) :7635-43.

• Background Reference 02:

  Rina Surgucheva , Belinda McMahon , Andrei Surguchov. Cell Motil Cytoskeleton. 2006 May 26.

• Other Product Names:

  BCSG1, PERSYN, PRSN, Breast cancer-specific gene 1 protein, SR, BCSG1

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  90110074