HDAC6 Antibody

CAT: 0223-7901-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7901-01Size:0.02 mg
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Background
The histone deacetylase (HDAC) family contains multiple members which are divided into four classes. Class II of the HDAC family comprises six members, HDAC4, 5, 6, 7, 9 and 10, each of which appear to have tissue-specific roles (1) . HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other (2) . HDAC6 has been shown to be part of the microtubule network and acts as a specific alpha-tubulin deacetylase, and has been suggested to be a potential therapeutic target in neurodegenerative disease (3) .
NCBI Gene ID
10013
Swiss Prot
Q9UBN7
Accession Number
NP_006035
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
HDAC6 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1313 - Human Testis Tissue Lysate
Concentration
1 mg/mL
Buffer
HDAC6 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
HDAC6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
HDAC6 antibody is human and mouse reactive. Multiple isoforms of HDAC6 are known to exist. HDAC6 antibody is predicted to not cross-react with other members of the HDAC family.
Symbol
HDAC6
Positive Control 2
Cat. No. 11-701 - Human Testis Tissue Slide
NCBI Official Name
Histone deacetylase 6
NCBI Organism
Homo sapiens
Background Reference 01
De Ruijter AJ, van Gennip AH, Caron HN, et al. Histone deacetylases (HDACs) : characterization of the classical HDAC family. Biochem. J. 2003; 370:737-49.
Background Reference 02
Grozinger CM, Hassig CA, and Schrieber SL. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. USA 1999; 96:4868-73.
Background Reference 03
Li G, Jiang H, Chang M, et al. HDAC6: a-tubulin decetylase: a potential therapeutic target in neurodegenerative disease. J. Neurol. Sci. 2011; 304:1-8.
Other Product Names
HDAC6 Antibody: HD6, JM21, CPBHM, KIAA0901, Histone deacetylase 6, HD6
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
13128864
Physical Properties
Liquid

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