HDAC6 Antibody

• Background :

  The histone deacetylase (HDAC) family contains multiple members which are divided into four classes. Class II of the HDAC family comprises six members, HDAC4, 5, 6, 7, 9 and 10, each of which appear to have tissue-specific roles (1) . HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other (2) . HDAC6 has been shown to be part of the microtubule network and acts as a specific alpha-tubulin deacetylase, and has been suggested to be a potential therapeutic target in neurodegenerative disease (3) .

• NCBI Gene ID :

  10013

• Swiss Prot :

  Q9UBN7

• Accession Number :

  NP_006035

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  HDAC6 antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1313 - Human Testis Tissue Lysate

• Concentration :

  1 mg/mL

• Buffer :

  HDAC6 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  HDAC6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment :

  IgG

• Specificity :

  HDAC6 antibody is human and mouse reactive. Multiple isoforms of HDAC6 are known to exist. HDAC6 antibody is predicted to not cross-react with other members of the HDAC family.

• Symbol :

  HDAC6

• Positive Control 2 :

  Cat. No. 11-701 - Human Testis Tissue Slide

• NCBI Official Name :

  Histone deacetylase 6

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  De Ruijter AJ, van Gennip AH, Caron HN, et al. Histone deacetylases (HDACs) : characterization of the classical HDAC family. Biochem. J. 2003; 370:737-49.

• Background Reference 02 :

  Grozinger CM, Hassig CA, and Schrieber SL. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. USA 1999; 96:4868-73.

• Background Reference 03 :

  Li G, Jiang H, Chang M, et al. HDAC6: a-tubulin decetylase: a potential therapeutic target in neurodegenerative disease. J. Neurol. Sci. 2011; 304:1-8.

• Other Product Names :

  HDAC6 Antibody: HD6, JM21, CPBHM, KIAA0901, Histone deacetylase 6, HD6

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  13128864

• Physical Properties :

  Liquid