TICRR Antibody

• Background:

  TopBP1-interacting checkpoint and replication regulator, Treslin, chromosome 15 open reading frame 42, C15ORF42

• NCBI Gene ID:

  90381

• Swiss Prot:

  Q7Z2Z1

• Accession Number:

  NP_689472

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  TICRR antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1308 - Human Small Intestine Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (74%)

• Buffer:

  TICRR antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TICRR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  TICRR antibody is human specific. At least two isoforms of TICRR are known to exist.

• Symbol:

  TICRR

• Positive Control 2:

  Cat. No. 11-801 - Human Small Intestine Tissue Slide

• NCBI Official Name:

  TOPBP1-interacting checkpoint and replication regulator

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sansam CL, Cruz NM, Danielian PS, et al. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev. 2010; 24:183-94.

• Background Reference 02:

  Kumagai A, Shevchenko A, Shevchenko A, et al. Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J. Cell Biol. 2011;193:995-1007.

• Background Reference 03:

  Kumagai A, Shevchenko A, Shevchenko A, et al. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 2010; 140:349-59.

• Background Reference 04:

  Mueller AC, Keaton MA, and Dutta A. DNA replication: mammalian Treslin-TopBP1 interaction mirrors yeast Sld3-Dpb11. Curr. Biol. 2011; 21:R638-40.

• Other Product Names:

  TICRR Antibody: SLD3, Treslin, C15orf42, TopBP1-interacting checkpoint and replication regulator

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  118421085

• Physical Properties:

  Liquid