TICRR Antibody - C-terminal

• Gene Name:

  TOPBP1 interacting checkpoint and replication regulator

• Gene Aliases:

  C15orf42; SLD3; topBP1-interacting checkpoint and replication regulator; topBP1-interacting replication-stimulating protein; TopBP1-interacting, replication-stimulating protein; treslin.

• Gene ID:

  90381

• Accession Number:

  https://www.ncbi.nlm.nih.gov/protein/NP_689472

• Reactivity:

  Human|Mouse

• Immunogen:

  TICRR antibody was raised against a 19 amino acid peptide near the carboxy terminus of human TICRR. The immunogen is located within amino acids 1840 - 1890 of TICRR.

• Target:

  Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC) . Required to prevent mitotic entry after treatment with ionizing radiation.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Format:

  Liquid. TICRR antibody is supplied in PBS containing 0.02% sodium azide.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  Predicted: 210 kDa Observed: 220 kDa

• Fragment:

  IgG

• NCBI Gene Symbol:

  TICRR

• Host or Source:

  Rabbit

• Protein Name:

  Treslin|treslin isoform 2 [Homo sapiens]

• Gene Name URL:

  TICRR

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001308025.1