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SREBF2 Antibody

CAT: 0223-7855-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7855-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The sterol regulatory element binding transcription factor 2 (SREBF2) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1,2) . The related protein SREBF1 also binds SRE1 and activates transcription in an additive fashion to SREBF2 (2) . SREBF2 has been more closely associated with cholesterol synthesis and accumulation, while the SREBF1 proteins are important in the regulation of genes involved in lipid metabolism (3) .
NCBI Gene ID
6721
Swiss Prot
Q12772
Accession Number
NP_004590
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
SREBF2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1216 - PC-3 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (100%)
Buffer
SREBF2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SREBF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SREBF2 antibody is human and mouse reactive. At least three isoforms of SREBF2 are known to exist. SREBF2 antibody is predicted not to cross-react with SREBF1.
Symbol
SREBF2
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Sterol regulatory element binding transcription factor 2
NCBI Organism
Homo sapiens
Background Reference 01
Hua X, Yokoyama C, Wu J, et al. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. USA 1993; 90:11603-7.
Background Reference 02
Wang X, Briggs MR, Hua X, et al. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. J. Biol. Chem. 1993; 268:14497-504.
Background Reference 03
Raghow R, Yellaturu C, Deng X, et al. SREBPs: the crossroads of physiological and pathological homeostasis. Endocrinol. Metab. 2008; 19:65-73.
Other Product Names
SREBF2 Antibody: SREBP2, bHLHd2, SREBP-2, BHLHD2, SREBP2, Sterol regulatory element-binding protein 2, Class D basic helix-loop-helix protein 2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
27477113
Physical Properties
Liquid

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