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DEPTOR Antibody

CAT: 0223-7787-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7787-01Size:0.02 mg
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Background
DEPTOR is an mTOR (mammalian target of rapamycin) -interacting protein whose expression is negatively regualted by mTOR complex 1 (mTORC1) and mTORC2 (1) . Loss of DEPTOR activates RP6SK1, Akt1, and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities. DEPTOR expression is low in most cancers, but is often elevated in multiple myelomas (1) . In respons to stimulation by mitogens, DEPTOR is rapidly phosphorylated leading to its ubiquitination and degradation, allowing mTOR to generate an auto-amplification loop to promotes its own full activation (2) .
NCBI Gene ID
64798
Swiss Prot
Q8TB45
Accession Number
NP_073620
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
DEPTOR antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1404 - Mouse Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
DEPTOR Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DEPTOR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
DEPTOR antibody is human, mouse and rat reactive. At least three isoforms of DEPTOR are known to exist; this antibody will detect all three isoforms.
Symbol
DEPTOR
NCBI Official Name
DEP domain containing MTOR-interacting protein
NCBI Organism
Homo sapiens
Background Reference 01
Peterson TR, Laplante M, Thoreen CC, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for survival. Cell 2009; 137:873-6.
Background Reference 02
Duan S, Skaar JR, Kuchay S, et al. mTOR generates an auto-amplification loop by triggering the bTrCP- and CK1a-dependent degradation of DEPTOR. Mol. Cell 2011; 44:317-24.
Other Product Names
DEPTOR Antibody: DEP.6, DEPDC6, DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6
Tested Applications
ELISA, WB, IHC-P
Protein ID
189571664
Physical Properties
Liquid

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