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ME1 Antibody

CAT: 0223-7721-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7721-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ME1, also known as NADP-ME, MES or HUMNDME, may play an important role as a housekeeping protein within the cell (1) . ME1 is a 572 amino acid cytoplasmic protein that belongs to the malic enzyme family (2) . It is expressed ubiquitously with highest expression in liver and white adipose tissue. ME1 functions as an NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis (3) . The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles (3,4) . ME1 is regulated by both thyroid hormone levels and the amount of carbohydrates in the diet (5) .
NCBI Gene ID
4199
Swiss Prot
P48163
Accession Number
NP_002386
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
ME1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
ME1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ME1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
ME1 antibody is human, mouse and rat reactive. ME1 antibody is predicted not to cross-react with ME2.
Symbol
ME1
NCBI Official Name
Malic enzyme 1, NADP (+) -dependent, cytosolic
NCBI Organism
Homo sapiens
Background Reference 01
Loeber G, Dworkin MB, Infante A, et al. Characterization of cytosolic malic enzyme in human tumor cells. FEBS Lett. 1994; 344:181-6.
Background Reference 02
Gonzalez-Manchon C, Ferrer M, Ayuso MS, et al. Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver. Gene 1995;159:255-60.
Background Reference 03
Gonzalez-Manchon C, Butta N, Ferrer M, et al. Molecular cloning and functional characterization of the human cytosolic malic enzyme promoter: thyroid hormone responsiveness. DNA Cell Biol. 1997;16:533-44.
Background Reference 04
Yang Z, Lanks CW and Tong L. Molecular mechanism for the regulation of human mitochondrial NAD (P) +-dependent malic enzyme by ATP and fumarate. Structure 2002; 10:951-60.
Other Product Names
ME1 Antibody: MES, HUMNDME, NADP-dependent malic enzyme, Malic enzyme 1, NADP-ME
Tested Applications
ELISA, WB, IHC-P
Protein ID
4505143
Physical Properties
Liquid

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