HMGB1 Recombinant Protein

• Background:

  HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.

• NCBI Gene ID:

  3146

• Swiss Prot:

  P40933

• Accession Number:

  NP_002119

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Innate Immunity, Other

• Buffer:

  Lyophilized from a concentrated sterile solution containing 50mM Tris-Hcl buffer (pH 8.0) and 100mM NaCl. Reconstituted in sterile H2O not less than 100 μ g/ml, which can then be further diluted in other aqueous solutions.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  High mobility group box 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  High Mobility Group Protein B1

• Species:

  Human

• Protein ID:

  4504425

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3