PPARGC1A Antibody

CAT: 0223-7705-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7705-01Size:0.02 mg
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Background
The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), also known as LEM-6, is a transcriptional coactivator that regulates the genes involved in energy metabolism (1) . PPARGC1A interacts with PPARgamma, which permits the interaction of PPARGC1A with multiple transcription factors. PPARGC1A can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs) . It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination (2) . PPARGC1A may be also involved in the development of obesity (3) .
NCBI Gene ID
10891
Swiss Prot
Q9UBK2
Accession Number
NP_037393
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
PPARGC1A antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1404 - Mouse Liver Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%)
Buffer
PPARGC1A antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PPARGC1A antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
PPARGC1A antibody is human, mouse and rat reactive. At least three isoforms of PPARGC1A are known to exist; this antibody only detects the longest isoform.
Symbol
PPARGC1A
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
Positive Control 3
Cat. No. 1304 – Human Liver Tissue Lysate
NCBI Official Name
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
NCBI Organism
Homo sapiens
Background Reference 01
Tsuemi T and La Spada AR. PGC-1a at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond. Prog. Neurobiol. 2012; 97:142-51.
Background Reference 02
Kang C and Li Ji L. Role of PGC-1a signaling in skeletal muscle health and disease. Ann. NY Acad. Sci. 2012; 1271:110-7.
Background Reference 03
Liu C and Lin JD. PGC-1 coactivators in the control of energy metabolism. Acta Biochim. Biophys. Sin. 2011; 43:248-57.
Other Product Names
PPARGC1A Antibody: LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1 (alpha), LEM6, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Ligand effect modulator 6, PGC-1-alpha
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
7019499
Physical Properties
Liquid

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