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PHC3 Antibody

CAT: 0223-7607-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7607-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development (1) . PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex (2) . PRC1 complex acts via chromatin remodeling and modification of histones. PHC3 contains 1 FCS-type zinc finger and SAM (sterile alpha motif) domain (2-3) . PHC 3 has been regarded as a candidate tumor suppressor of osteosarcoma (4) .
NCBI Gene ID
80012
Swiss Prot
Q8NDX5
Accession Number
NP_079223
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
PHC3 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1282 - 3T3 (NIH) Cell Lysate
Concentration
1 mg/mL
Buffer
PHC3 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PHC3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
PHC3 antibody is human, mouse and rat specific. At least six isoforms of PHC3 are known to exist.
Symbol
PHC3
NCBI Official Name
Polyhomeotic homolog 3 (Drosophila)
NCBI Organism
Homo sapiens
Background Reference 01
Valk-Lingbeek ME, Bruggeman SW, and Van Lohuizen M. Stem cells and cancer; the polycomb connection. Cell 2004; 118:409–18.
Background Reference 02
Deshpande AM, Akunowicz JD, Reveles XT, et al. PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. Oncogene 2007; 26:1714-22.
Background Reference 03
Isono K, Fujimura Y, Shinga J, et al. Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Mol. Cell Biol. 2005; 25:6694-706.
Background Reference 04
Iwata S, Takenobu H, Kageyama H, et al. Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma. Cancer Sci. 2010; 101:1646-52.
Other Product Names
PHC3 Antibody: EDR3, HPH3, EDR3, PH3, Polyhomeotic-like protein 3, Early development regulatory protein 3, hPH3
Tested Applications
ELISA, WB
Protein ID
148612879
Physical Properties
Liquid

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