DNM1L Antibody

• Background:

  The Dynamin-1-like protein (DNM1L) is a member of the dynamin superfamily of GTPases (1) . DNM1L mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis (2) . Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) (3) .

• NCBI Gene ID:

  10059

• Swiss Prot:

  O00429

• Accession Number:

  NP_036192

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis

• Purification:

  DNM1L antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (100%)

• Buffer:

  DNM1L antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  DNM1L antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  DNM1L antibody is human and mouse reactive. At least four isoforms of DNM1L are known to exist; this antibody will detect the two longest isoforms.

• Symbol:

  DNM1L

• Positive Control 2:

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name:

  Dynamin 1-like

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shin HW, Shinotsuka C, Torii S, et al. Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p. J. Biochem. 1997; 122:525-30.

• Background Reference 02:

  Frank S, Gaume B, Bergmann-Leitner ES, et al. The role of dynamin-related protein1, a mediator of mitochondrial fission, in apoptosis. Dev. Cell 2001; 1:515-25.

• Background Reference 03:

  Reddy PH, Reddy TP, Manczak M, et al. Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Res. Rev. 2011; 67:103-18.

• Other Product Names:

  DNM1L Antibody: DLP1, DRP1, DVLP, EMPF, DYMPLE, HDYNIV, DLP1, Dynamin-1-like protein, Dynamin family member proline-rich carboxyl-terminal domain less

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  171460914

• Physical Properties:

  Liquid