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DDX41 Antibody

CAT: 0223-7349-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7349-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DDX41 Antibody: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DDX41, also known as Abstrakt, interacts with and regulates the expression of sorting nexin-2 (SNX2), a protein involved in protein sorting in the trans-Golgi network. Recent evidence suggests that DDX41 also plays a role in the innate immune response by sensing intracellular viral DNA, triggering TBK1 and IRF3 activation, leading to a type I interferon immune response.
NCBI Gene ID
51428
Swiss Prot
Q9UJV9
Accession Number
NP_057306
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
DDX41 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
DDX41 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DDX41 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
At least two isoforms of DDX41 are known to exist; this antibody will detect both isoforms.
Symbol
DDX41
NCBI Official Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
NCBI Organism
Homo sapiens
Background Reference 01
Cordin O, Banroques J, Tanner NK, et al. The DEAD-box protein family of RNA helicases. Gene 2006; 367:17-37.
Background Reference 02
Linder P. Dead-box proteins: a family affair—active and passive players in RNP-remodeling. Nucleic Acids Res. 2006; 34:4168-80.
Background Reference 03
Abdul-Ghani M, Hartman KL, and Ngsee JK. Abstrakt interacts with and regulates the expression of sorting nexin-2. J. Cell Physiol. 2005; 204:210-8.
Background Reference 04
Zhang Z, Yuan B, Bao M, et al. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 2011; 12:959-65.
Other Product Names
DDX41 Antibody: ABS, ABS, Probable ATP-dependent RNA helicase DDX41, DEAD box protein 41
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
21071032
Physical Properties
Liquid

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