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PRKCDBP Antibody

CAT: 0223-7269-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7269-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PRKCDBP Antibody: The protein kinase C delta (PKC-δ ) binding protein (PRKCDBP), also known as cavin-3, is a member of the cavin family of proteins that are involved in caveolin formation and regulation. PRKCDBP was initially identified in a screen of cultured cell lines for proteins that were strongly induced by serum starvation. Studies indicate that PRKCDBP binds not only to PKC-δ but also to caveolin-1 and helps regulate caveolin traffic and function. Similar to other members of the cavin family, the expression of PRKCDBP was found to be down-regulated in various cancer cell lines, suggesting a possible tumor suppressor function of PRKCDBP.
NCBI Gene ID
112464
Swiss Prot
Q969G5
Accession Number
NP_659477
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
PRKCDBP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (100%)
Buffer
PRKCDBP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PRKCDBP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
29 kDa
Fragment
IgG
Specificity
It is predicted to not cross-react with other members of the cavin family.
Symbol
PRKCDBP
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Protein kinase C, delta binding protei
NCBI Organism
Homo sapiens
Background Reference 01
Briand N, Dugail I, and Le Lay S. Cavin proteins: New players in the caveolae field. Biochimie 2011; 93:71-7.
Background Reference 02
Izumi Y, Hirai S, Tamai Y, et al. A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. J. Biol. Chem. 1997; 272:7381-9.
Background Reference 03
McMahon K, Zajicek H, Li W, et al. SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. EMBO J. 2009; 28:1001-15.
Background Reference 04
Bai L, Deng X, Li Q, et al. Down-regulation of the cavin family proteins in breast cancer. J. Cell Biochem. 2012; 113:322-8.
Other Product Names
PRKCDBP Antibody: SRBC, HSRBC, CAVIN3, cavin-3, SRBC, Protein kinase C delta-binding protein, Cavin-3, hSRBC
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
47132587
Physical Properties
Liquid

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